The highly enantioselective Michael addition of ketones to nitrodienes catalyzed by the efficient organocatalyst system of pyrrolidinyl-thioimidazole and chiral thioureido acid

The highly enantioselective Michael addition reaction of ketones to nitrodienes was promoted efficiently by the accessible and fine-tunable organocatalytic system of pyrrolidinyl-thioimidazole and chiral thioureido acid. The corresponding adducts were afforded in good yields with high diastereoselec...

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Veröffentlicht in:Organic & biomolecular chemistry 2010-01, Vol.8 (11), p.2505-2508
Hauptverfasser: Li, Zhao-Bo, Luo, Shu-Ping, Guo, Yi, Xia, Ai-Bao, Xu, Dan-Qian
Format: Artikel
Sprache:eng
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Zusammenfassung:The highly enantioselective Michael addition reaction of ketones to nitrodienes was promoted efficiently by the accessible and fine-tunable organocatalytic system of pyrrolidinyl-thioimidazole and chiral thioureido acid. The corresponding adducts were afforded in good yields with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).
ISSN:1477-0520
1477-0539
DOI:10.1039/c002197k