Scalable Synthesis of Cryptophane-1.1.1 and its Functionalization

Scalable Synthesis of Cryptophane-1.1.1 and its Functionalization

Cryptophanes, cage molecules for which xenon exhibits a high affinity, are good candidates for xenon biosensing. Cryptophane-1.1.1 (1) exhibits the highest binding constant for xenon encapsulation in organic solution determined to date. This property suggests that the cryptophane-1.1.1 core (1) is o...

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Veröffentlicht in:Organic letters 2010-03, Vol.12 (5), p.960-962
Hauptverfasser: Traoré, Ténin, Delacour, Léa, Garcia-Argote, Sébastien, Berthault, Patrick, Cintrat, Jean-Christophe, Rousseau, Bernard
Format: Artikel
Sprache:eng
Schlagworte:
Dimerization
Phenol - chemistry
Polycyclic Compounds
Triazoles - chemical synthesis
Triazoles - chemistry
Xenon - analysis
Xenon - chemistry
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Zusammenfassung:Cryptophanes, cage molecules for which xenon exhibits a high affinity, are good candidates for xenon biosensing. Cryptophane-1.1.1 (1) exhibits the highest binding constant for xenon encapsulation in organic solution determined to date. This property suggests that the cryptophane-1.1.1 core (1) is optimal for sensing applications. A high-yielding scalable synthesis of compound 1 is reported as well as an easy way to functionalize it.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol902952h