Synthesis and Biological Evaluation of Heteroanalogues of Kotalanol and De-O-Sulfonated Kotalanol

The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2010-03, Vol.12 (5), p.1088-1091
Hauptverfasser:	Mohan, Sankar, Jayakanthan, Kumarasamy, Nasi, Ravindranath, Kuntz, Douglas A, Rose, David R, Pinto, B. Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors Humans Intestines - enzymology Monosaccharides - chemical synthesis Monosaccharides - chemistry Monosaccharides - pharmacology Structure-Activity Relationship Sulfates - chemical synthesis Sulfates - chemistry Sulfates - pharmacology Sulfonic Acids - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol100080m