Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss. In the ME7 model of prion disease in the C57BL/6 J mouse, we have shown previously that these animals display behav...

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Veröffentlicht in:	The European journal of neuroscience 2003-05, Vol.17 (10), p.2147-2155
Hauptverfasser:	Cunningham, C., Deacon, R., Wells, H., Boche, D., Waters, S., Diniz, C. Picanco, Scott, H., Rawlins, J. N. P., Perry, V. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - pathology Behavior, Animal Cell Death Eating Female Glucose - pharmacology hippocampus Homeostasis Mice Mice, Inbred C57BL Microglia - pathology Motor Activity Nerve Degeneration - pathology Nesting Behavior neurodegeneration neuronal dysfunction Neurons - chemistry Neurons - pathology Prion Diseases - pathology PrPSc Proteins - analysis scrapie synapse Synapses - pathology Synaptophysin - analysis
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