A "Clickable" Hybrid Nanocluster of Cubic Symmetry

Platonic scaffold: Octa(azidopropyl) cube‐octameric silsesquioxane is a versatile scaffold for uniform eightfold symmetric decoration by efficient Huisgen‐type 1,3‐dipolar cycloaddition under both thermal and CuI‐catalyzed conditions (see scheme). Applications are demonstrated for the formation of glycoclusters, as well as an entry to dendrimer synthesis by functional azide‐to‐alkyne reversion with implicit doubling to sixteenfold attachment sites.