Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation

Be dazzled by the sequence: The first efficient and general one‐pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6‐di‐tert‐butyl‐4‐methylpyridine, Tf=trifluoromethanesulfonyl).

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2010-04, Vol.49 (17), p.3037-3040
Hauptverfasser: Xiao, Kai-Jiong, Luo, Jie-Min, Ye, Ke-Yin, Wang, Yu, Huang, Pei-Qiang
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
amides
Amides - chemistry
Amines - chemical synthesis
Amines - chemistry
Combinatorial Chemistry Techniques - methods
Lactams - chemistry
Lithium Compounds - chemistry
multicomponent reactions
Oxidation-Reduction
sequential reductive alkylation
synthetic methods
tert-alkylamines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Be dazzled by the sequence: The first efficient and general one‐pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6‐di‐tert‐butyl‐4‐methylpyridine, Tf=trifluoromethanesulfonyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000652