Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats

The study was designed to evaluate the possible hepatoprotective effect of Cnidoscolus aconitifolius on paracetamol poisoning in rats. Twenty five male Wistar rats were used in this study. They were divided into 5 groups of 5 rats. Groups I and II received normal saline (0.9% physiological saline)....

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Veröffentlicht in:	Pakistan journal of biological sciences 2010-02, Vol.13 (4), p.164-169
Hauptverfasser:	Oyagbemi, A A, Odetola, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Ethanol - chemistry Euphorbiaceae - chemistry Liver - drug effects Liver - metabolism Liver - pathology Liver Diseases - drug therapy Male Plant Extracts - pharmacology Plant Extracts - therapeutic use Random Allocation Rats Rats, Wistar
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Zusammenfassung:	The study was designed to evaluate the possible hepatoprotective effect of Cnidoscolus aconitifolius on paracetamol poisoning in rats. Twenty five male Wistar rats were used in this study. They were divided into 5 groups of 5 rats. Groups I and II received normal saline (0.9% physiological saline). Animal in groups III-V were administered Cnidoscolus aconitifolius at 100, 500 and 1,000 mg kg(-1), respectively for 7 days. All animal in groups II-V were given paracetamol at 3 g kg(-1) by gastric gavage on days 8 and 9. Animals were sacrificed by cervical dislocation on day 10 after an overnight fast. Paracetamol overdose caused significant (p
ISSN:	1028-8880
DOI:	10.3923/pjbs.2010.164.169