Stimulation of serum-free cell proliferation by Coenzyme Q
Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also sti...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1992-11, Vol.189 (1), p.8-13 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Sun, I.L. Sun, E.E. Crane, F.L. |
| description | Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also stimulate cell growth, but vitamin K
1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation. |
| doi_str_mv | 10.1016/0006-291X(92)91517-T |
| format | Article |
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1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(92)91517-T</identifier><identifier>PMID: 1449508</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>3T3 Cells ; Animal cells ; Animals ; Biological and medical sciences ; Cell cultures. Hybridization. Fusion ; Cell Division - drug effects ; Coenzymes ; Culture Media, Serum-Free ; Dose-Response Relationship, Drug ; Ferricyanides - pharmacology ; Fundamental and applied biological sciences. Psychology ; HeLa Cells ; Humans ; Insulin - pharmacology ; Kinetics ; Mice ; Molecular and cellular biology ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology ; Vitamin E - analogs & derivatives ; Vitamin E - pharmacology ; Vitamin K 1 - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1992-11, Vol.189 (1), p.8-13</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-38bacf008cfc213bd09f149cd4334351be987066573b879344799d826fd08f663</citedby><cites>FETCH-LOGICAL-c386t-38bacf008cfc213bd09f149cd4334351be987066573b879344799d826fd08f663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(92)91517-T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4492945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1449508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, I.L.</creatorcontrib><creatorcontrib>Sun, E.E.</creatorcontrib><creatorcontrib>Crane, F.L.</creatorcontrib><title>Stimulation of serum-free cell proliferation by Coenzyme Q</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also stimulate cell growth, but vitamin K
1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation.</description><subject>3T3 Cells</subject><subject>Animal cells</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell cultures. Hybridization. Fusion</subject><subject>Cell Division - drug effects</subject><subject>Coenzymes</subject><subject>Culture Media, Serum-Free</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ferricyanides - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Insulin - pharmacology</subject><subject>Kinetics</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><subject>Vitamin E - analogs & derivatives</subject><subject>Vitamin E - pharmacology</subject><subject>Vitamin K 1 - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOo7-A4UuRHRRvWnSNHEhyOALBBFHcBfa9AYifYxJK4y_3o4dxp2ru7jfORw-Qo4oXFCg4hIARJwo-n6mknNFU5rF8y0yoaAgTijwbTLZIHtkP4QPAEq5ULtkl3KuUpATcvXaubqv8s61TdTaKKDv69h6xMhgVUUL31bOoh-BYhnNWmy-lzVGLwdkx-ZVwMP1nZK3u9v57CF-er5_nN08xYZJ0cVMFrmxANJYk1BWlKAs5cqUnDHOUlqgkhkIkWaskJlinGdKlTIRtgRphWBTcjr2Dls-ewydrl1YjcsbbPugs6FHZkwNIB9B49sQPFq98K7O_VJT0CtleuVDr3xolehfZXo-xI7X_X1RY_kXGh0N_5P1Pw8mr6zPG-PCBhuoRPF0wK5HDAcXXw69DsZhY7B0Hk2ny9b9v-MH4AuGbw</recordid><startdate>19921130</startdate><enddate>19921130</enddate><creator>Sun, I.L.</creator><creator>Sun, E.E.</creator><creator>Crane, F.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921130</creationdate><title>Stimulation of serum-free cell proliferation by Coenzyme Q</title><author>Sun, I.L. ; Sun, E.E. ; Crane, F.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-38bacf008cfc213bd09f149cd4334351be987066573b879344799d826fd08f663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>3T3 Cells</topic><topic>Animal cells</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell cultures. Hybridization. Fusion</topic><topic>Cell Division - drug effects</topic><topic>Coenzymes</topic><topic>Culture Media, Serum-Free</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ferricyanides - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Insulin - pharmacology</topic><topic>Kinetics</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Ubiquinone - pharmacology</topic><topic>Vitamin E - analogs & derivatives</topic><topic>Vitamin E - pharmacology</topic><topic>Vitamin K 1 - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, I.L.</creatorcontrib><creatorcontrib>Sun, E.E.</creatorcontrib><creatorcontrib>Crane, F.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, I.L.</au><au>Sun, E.E.</au><au>Crane, F.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of serum-free cell proliferation by Coenzyme Q</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1992-11-30</date><risdate>1992</risdate><volume>189</volume><issue>1</issue><spage>8</spage><epage>13</epage><pages>8-13</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also stimulate cell growth, but vitamin K
1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1449508</pmid><doi>10.1016/0006-291X(92)91517-T</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1992-11, Vol.189 (1), p.8-13 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 3T3 Cells Animal cells Animals Biological and medical sciences Cell cultures. Hybridization. Fusion Cell Division - drug effects Coenzymes Culture Media, Serum-Free Dose-Response Relationship, Drug Ferricyanides - pharmacology Fundamental and applied biological sciences. Psychology HeLa Cells Humans Insulin - pharmacology Kinetics Mice Molecular and cellular biology Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Vitamin E - analogs & derivatives Vitamin E - pharmacology Vitamin K 1 - pharmacology |
| title | Stimulation of serum-free cell proliferation by Coenzyme Q |
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