Stimulation of serum-free cell proliferation by Coenzyme Q

Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also sti...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-11, Vol.189 (1), p.8-13
Hauptverfasser:	Sun, I.L., Sun, E.E., Crane, F.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animal cells Animals Biological and medical sciences Cell cultures. Hybridization. Fusion Cell Division - drug effects Coenzymes Culture Media, Serum-Free Dose-Response Relationship, Drug Ferricyanides - pharmacology Fundamental and applied biological sciences. Psychology HeLa Cells Humans Insulin - pharmacology Kinetics Mice Molecular and cellular biology Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Vitamin E - analogs & derivatives Vitamin E - pharmacology Vitamin K 1 - pharmacology
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Beschreibung
Zusammenfassung:	Coenzyme Q added to culture media stimulates the growth of HeLa and Balb/3T3 cells in serum free conditions. The stimulation by coenzyme Q is additive to the stimulation by ferricyanide, an impermeable electron acceptor for the transplasma membrane electron transport. αTocopherylquinone can also stimulate cell growth, but vitamin K 1 is inactive or inhibitory. The response to coenzyme Q and ferricyanide is enhanced with insulin. A contribution to plasma membrane NADH oxidation or modification of the membrane quinone redox balance can be a basis for the growth stimulation.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(92)91517-T