Selective Ruthenium-Catalyzed N-Alkylation of Indoles by Using Alcohols

Selective Ruthenium-Catalyzed N-Alkylation of Indoles by Using Alcohols

Alcohols for alkylation! The first homogeneous‐catalyzed N‐alkylations of indoles with aliphatic alcohols proceed under transfer hydrogenation conditions. By the use of the Shvo catalyst and p‐toluenesulfonic acid (PTSA) this atom‐efficient reaction occurs highly selectively with water formed as the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry : a European journal 2010-03, Vol.16 (12), p.3590-3593
Hauptverfasser: Bähn, Sebastian, Imm, Sebastian, Mevius, Kathleen, Neubert, Lorenz, Tillack, Annegret, Williams, Jonathan M. J., Beller, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Alcohols - chemistry
Aliphatic alcohols
Alkylation
Byproducts
Catalysis
Catalysts
Chemistry
Deuterium Exchange Measurement
homogeneous catalysis
hydrogen transfer
Hydrogenation
Indoles
Indoles - chemistry
ruthenium
Ruthenium - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Alcohols for alkylation! The first homogeneous‐catalyzed N‐alkylations of indoles with aliphatic alcohols proceed under transfer hydrogenation conditions. By the use of the Shvo catalyst and p‐toluenesulfonic acid (PTSA) this atom‐efficient reaction occurs highly selectively with water formed as the only byproduct (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200903144