Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (17), p.3004-3006
Hauptverfasser:	Qian, Yong, Ma, Gaoyuan, Lv, Aifeng, Zhu, Hai-Liang, Zhao, Jing, Rawal, Viresh H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Catalysis Imines - chemical synthesis Imines - chemistry Indoles - chemistry Stereoisomerism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b922120d