Randomised comparison of amniocentesis and transabdominal and transcervical chorionic villus sampling

Randomised comparison of amniocentesis and transabdominal and transcervical chorionic villus sampling

We have compared three methods of prenatal diagnosis in two large obstetric centres in Denmark. Women were randomly assigned transabdominal (TA) chorionic villus sampling (CVS), transcervical (TC) CVS, or second-trimester amniocentesis (AC); women at high genetic risk were randomised between the two...

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Veröffentlicht in:The Lancet (British edition) 1992-11, Vol.340 (8830), p.1237-1244
Hauptverfasser: Smidt-Jensen, S., Philip, J., Lundsteen, C., Permin, M., Zachary, J.M., Fowler, S.E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Amniocentesis
Biological and medical sciences
Chorionic Villi Sampling - methods
Female
Fetuses
Gynecology. Andrology. Obstetrics
Humans
Management. Prenatal diagnosis
Medical research
Medical sciences
Pregnancy
Pregnancy. Fetus. Placenta
Tests
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Zusammenfassung:We have compared three methods of prenatal diagnosis in two large obstetric centres in Denmark. Women were randomly assigned transabdominal (TA) chorionic villus sampling (CVS), transcervical (TC) CVS, or second-trimester amniocentesis (AC); women at high genetic risk were randomised between the two CVS groups only. Analysis of 45 epidemiological variables showed the three procedure groups to be similar at enrolment. All women were followed up until completion of pregnancy. Among 3079 women at low genetic risk total fetal loss rates were 10·9% for TC CVS, 6·3% for TACVS, and 6·4% for AC (p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(92)92946-D