Synthesis of a Novel cis-Proline-Derived Cyclic Type VI β-Turn Mimic via Ring-Closing Metathesis

A cis-proline derived cyclic mimic of a type VI β-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa β-turn in CDCl3 and a type VIb β-turn in DMSO-d 6.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2003-06, Vol.68 (12), p.5006-5008
Hauptverfasser:	Boruah, Anima, Rao, I. Nageshwar, Nandy, Jyoti Prokash, Kumar, S. Kiran, Kunwar, A. C, Iqbal, Javed
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Cyclization Exact sciences and technology Lipids Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Molecular Mimicry Molecular Structure Organic chemistry Peptides, Cyclic - chemical synthesis Preparations and properties Proline - chemistry Protein Structure, Secondary Stereoisomerism
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Beschreibung
Zusammenfassung:	A cis-proline derived cyclic mimic of a type VI β-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa β-turn in CDCl3 and a type VIb β-turn in DMSO-d 6.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo020618m