“Pure by NMR”?

“Pure by NMR”?

Integration of a 13C−1H satellite peak of a given 12C−1H parent resonance within a quantitative 1H NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).

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Veröffentlicht in:Organic letters 2008-12, Vol.10 (23), p.5433-5436
Hauptverfasser: Claridge, Timothy D. W, Davies, Stephen G, Polywka, Mario E. C, Roberts, Paul M, Russell, Angela J, Savory, Edward D, Smith, Andrew D
Format: Artikel
Sprache:eng
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Zusammenfassung:Integration of a 13C−1H satellite peak of a given 12C−1H parent resonance within a quantitative 1H NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802211p