A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2010-04, Vol.12 (7), p.1616-1619
Hauptverfasser: Inokoishi, Yogo, Sasakura, Niiha, Nakano, Keiji, Ichikawa, Yoshiyasu, Kotsuki, Hiyoshizo
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemical synthesis
Alkenes - chemistry
Carbon - chemistry
Catalysis
Cyclohexanones - chemical synthesis
Cyclohexanones - chemistry
Diamines - chemistry
Molecular Structure
Phenols - chemical synthesis
Phenols - chemistry
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100350w