Cobalt Catalysis at the Crossroads: Cobalt-Catalyzed Alder−Ene Reaction versus [2 + 2] Cycloaddition

Cobalt Catalysis at the Crossroads: Cobalt-Catalyzed Alder−Ene Reaction versus [2 + 2] Cycloaddition

The application of bidentate phosphine ligands in cobalt-catalyzed transformations of cyclic alkenes such as cyclopentene and cycloheptene with internal alkynes led to a chemoselective Alder−ene or a [2 + 2] cycloaddition reaction depending on the electronic nature of the alkyne and the bite angle o...

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Veröffentlicht in:Organic letters 2010-04, Vol.12 (7), p.1536-1539
Hauptverfasser: Hilt, Gerhard, Paul, Anna, Treutwein, Jonas
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemical synthesis
Alkenes - chemistry
Catalysis
Cobalt - chemistry
Cyclization
Molecular Structure
Organometallic Compounds - chemistry
Stereoisomerism
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Zusammenfassung:The application of bidentate phosphine ligands in cobalt-catalyzed transformations of cyclic alkenes such as cyclopentene and cycloheptene with internal alkynes led to a chemoselective Alder−ene or a [2 + 2] cycloaddition reaction depending on the electronic nature of the alkyne and the bite angle of the ligand used.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol100266u