Catalytic Asymmetric Si----O Coupling of Simple Achiral Silanes and Chiral Donor-Functionalized Alcohols

Catalytic Asymmetric Si----O Coupling of Simple Achiral Silanes and Chiral Donor-Functionalized Alcohols

Silicon alley: SiH and HOR are enantioselectively coupled in the presence of a chiral CuH complex. In this way, the kinetic resolution of racemic mixtures of alcohols is accomplished through asymmetric protection with standard silanes (see scheme; R=aryl or alkyl, Ar=3,5‐xylyl, Np=2‐naphthyl; s=s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2010-03, Vol.49 (12), p.2223-2226
Hauptverfasser: Weickgenannt, Andreas, Mewald, Marius, Muesmann, Thomas W.T, Oestreich, Martin
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
dehydrogenative coupling
kinetic resolution
monodentate ligands
silicon
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Silicon alley: SiH and HOR are enantioselectively coupled in the presence of a chiral CuH complex. In this way, the kinetic resolution of racemic mixtures of alcohols is accomplished through asymmetric protection with standard silanes (see scheme; R=aryl or alkyl, Ar=3,5‐xylyl, Np=2‐naphthyl; s=selectivity factor).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200905561