What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?

Antimicrobial peptides are effector molecules of innate immunity with microbicidal and pro- or anti-inflammatory activities. Their role is now widening following evidence that one such multifunctional peptide, LL-37, induces angiogenesis, a process essential for host defense, wound healing, and tiss...

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Veröffentlicht in:	The Journal of clinical investigation 2003-06, Vol.111 (11), p.1643-1645
1. Verfasser:	Elsbach, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antimicrobial Cationic Peptides - pharmacology Biomedical research Cathelicidins Humans Inflammation - drug therapy Models, Biological Neovascularization, Pathologic Peptides - chemistry Prodrugs - pharmacology Ribonuclease, Pancreatic - chemistry
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Beschreibung
Zusammenfassung:	Antimicrobial peptides are effector molecules of innate immunity with microbicidal and pro- or anti-inflammatory activities. Their role is now widening following evidence that one such multifunctional peptide, LL-37, induces angiogenesis, a process essential for host defense, wound healing, and tissue repair.
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCI18761