Efficacy of topical tacrolimus 0.3% in clobetasol propionate 0.05% ointment in therapy-resistant cutaneous lupus erythematosus: a cohort study

Summary Background.  Despite a range of available topical and systemic therapies, treatment of cutaneous lupus erythematosus (CLE) can be challenging. Objectives.  To evaluate the efficacy of a specially formulated preparation of tacrolimus 0.3% in clobetasol propionate 0.05% ointment (TCPO) in the...

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Veröffentlicht in:Clinical and experimental dermatology 2010-01, Vol.35 (1), p.27-30
Hauptverfasser: Madan, V., August, P. J., Chalmers, R. J. G.
Format: Artikel
Sprache:eng
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Zusammenfassung:Summary Background.  Despite a range of available topical and systemic therapies, treatment of cutaneous lupus erythematosus (CLE) can be challenging. Objectives.  To evaluate the efficacy of a specially formulated preparation of tacrolimus 0.3% in clobetasol propionate 0.05% ointment (TCPO) in the treatment of CLE. Methods.  Case notes of 13 patients with treatment‐resistant CLE (11 discoid LE, 1 systemic LE and 1 subacute cutaneous LE) who had used twice‐daily TCPO (TCPO group) were reviewed. These were compared with five similar patients with resistant CLE who had been given 0.1% tacrolimus ointment alone (TO group). Results.  In the TCPO group (mean treatment duration 20 months, range 1–72), a good or excellent response was seen in five and six patients, respectively; one patient showed slight improvement. Telangiectasia and acne were observed in two patients. No systemic side‐effects were noted. In the TO group (mean treatment duration 6 months, range 1–24), one patient showed good improvement and two showed slight improvement. Conclusion.  The results of our small retrospective study suggest that TCPO may be more effective than either 0.1% tacrolimus or clobetasol propionate 0.05% ointment monotherapy in the treatment of recalcitrant CLE. Randomized controlled trials are needed to confirm these preliminary findings.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.2009.03351.x