Activity of MMP-2 and MMP-9 in sera of breast cancer patients

Gelatinase A (MMP-2) and gelatinase B (MMP-9) are proteolytic enzymes involved in the process of tumor invasion, and they are considered as possible tumor markers in breast cancer patients. In this study, we examined serum activity of proMMP-2 and proMMP-9 in relation to TNM stage, tumor size, lymph...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2010-04, Vol.206 (4), p.241-247
Hauptverfasser:	Stankovic, Sandra, Konjevic, Gordana, Gopcevic, Kristina, Jovic, Viktor, Inic, Momcilo, Jurisic, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - blood Breast cancer Breast Neoplasms - blood Breast Neoplasms - enzymology Carcinoma, Ductal, Breast - blood Carcinoma, Ductal, Breast - enzymology Clinicopathological markers Electrophoresis, Polyacrylamide Gel Enzyme Precursors - blood Female Humans Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood MMP-2 MMP-9 Neoplasm Staging Serum Statistics, Nonparametric
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Zusammenfassung:	Gelatinase A (MMP-2) and gelatinase B (MMP-9) are proteolytic enzymes involved in the process of tumor invasion, and they are considered as possible tumor markers in breast cancer patients. In this study, we examined serum activity of proMMP-2 and proMMP-9 in relation to TNM stage, tumor size, lymph node involvement, grade of differentiation of tumors, as well as steroid and Her2/neu receptor status in breast cancer patients. The activity of gelatinase in the sera of 52 patients was analyzed by SDS-PAGE zymography. The activity of proMMP-2 and proMMP-9 significantly increased with each advancing clinical stage of disease ( p=0.02–0.0009) and compared to controls ( p=0.015 to p
ISSN:	0344-0338 1618-0631
DOI:	10.1016/j.prp.2009.12.003