Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody

Cytokinesis is the process by which a single cell divides into two physically distinct daughter cells; however, the molecular details of this fundamental process remain largely unknown . In animal cells, cytokinesis usually consists of four stages： selection of the cleavage site, assembly of the cleavage furrow, ingression of the cleavage furrow, and abscission of the cell .