Melatonin in rat pineal gland and serum; rapid parallel decline after light exposure at night

Melatonin content in the rat pineal decreases at night after exposure of animals to light, from 20 to 2 pmol/gland in 15 min. Melatonin concentration in serum fell precipitously in a manner almost identical to the drop in pineal melatonin only with a 5 min time lag. It is concluded that the rapid de...

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Veröffentlicht in:Neuroscience letters 1978-09, Vol.9 (2), p.189-193
Hauptverfasser: Illnerova, Helena, Backström, Maria, Sääf, Jan, Wetterberg, Lennart, Vangbo, Birgitta
Format: Artikel
Sprache:eng
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Zusammenfassung:Melatonin content in the rat pineal decreases at night after exposure of animals to light, from 20 to 2 pmol/gland in 15 min. Melatonin concentration in serum fell precipitously in a manner almost identical to the drop in pineal melatonin only with a 5 min time lag. It is concluded that the rapid decrease in the pineal melatonin content is mainly due to an inhibited synthesis of melatonin.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(78)90070-8