Studies in vivo of ribonucleic acid turnover in mice (strain C57 BL/6J) homozygous and heterozygous for the dystrophic gene, dy(2J)

In vivo incorporation of [5-(3)H]uridine into RNA of 40-day-old mice, homozygous and heterozygous for the dy(2J) dystrophic allele, has been examined. Increased incorporation is seen in leg skeletal muscle but no increase is liver tissue. Determination of DNA and RNA content of the muscle tissue examined showed that the increased incorporation was not due to muscle volume changes that are associated with wasting in dystrophic muscle. The results obtained with the dy(2J) allele are discussed with respect to related investigation with the dy dystrophic allele.