Chemiluminescence Assay Improves Specificity of Hepatitis C Antibody Detection

Antibodies to hepatitis C virus (anti-HCV) have typically been detected by enzyme immunoassay (EIA). A chemiluminescence assay (CA) for anti-HCV is now commercially available. We compared the positive rate for a CA in a HCV screening program for veterans with historical rates obtained with EIA. We a...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2003-06, Vol.49 (6), p.940-944
Hauptverfasser:	Dufour, D. Robert, Talastas, Mageli, Fernandez, Maria D.A, Harris, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Biological and medical sciences Chemiluminescence False Positive Reactions Hepacivirus - immunology Hepatitis Hepatitis C Human viral diseases Humans Immunoblotting Immunoenzyme Techniques Infectious diseases Luminescent Measurements Mass Screening Medical sciences Sensitivity and Specificity Veterans Viral diseases Viral hepatitis
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Zusammenfassung:	Antibodies to hepatitis C virus (anti-HCV) have typically been detected by enzyme immunoassay (EIA). A chemiluminescence assay (CA) for anti-HCV is now commercially available. We compared the positive rate for a CA in a HCV screening program for veterans with historical rates obtained with EIA. We also compared results in 2824 samples tested by both methods and assessed the significance of low signal-to-cutoff (S/C) ratios. The frequency of CA-positive results was significantly lower than with EIA (12.6% vs 16.0%; P
ISSN:	0009-9147 1530-8561
DOI:	10.1373/49.6.940