Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice

Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and anti-inflammatory properties, but its oral bioavailability is very poor and this becomes difficult to assess its therapeutic potential. Here we have compared the anti-inflammatory effect of quercetin-loaded microemulsion (QU...

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Veröffentlicht in:	Pharmacological research 2010-04, Vol.61 (4), p.288-297
Hauptverfasser:	Rogerio, Alexandre P., Dora, Cristiana L., Andrade, Edinéia L., Chaves, Juliana S., Silva, Luis F.C., Lemos-Senna, Elenara, Calixto, João B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Airways allergic inflammation Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Asthma - blood Asthma - chemically induced Asthma - drug therapy Asthma - immunology Asthma - metabolism Disease Models, Animal Drug Carriers - administration & dosage Drug Carriers - chemistry Emulsions - administration & dosage Emulsions - chemistry Eosinophils Female Inflammation Mediators - metabolism Leukocyte Count Lung - drug effects Lung - immunology Lung - metabolism Mice Mice, Inbred BALB C NF-kappa B - metabolism Oral bioavailability P-Selectin - metabolism Particle Size Quercetin - administration & dosage Quercetin - chemistry Quercetin - pharmacology Quercetin-loaded microemulsion Respiratory Mucosa - drug effects Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Suspensions
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