Comparison of Porcine Pulmonary and Aortic Root Material Properties

Background The pulmonary autograft remodels when subjected to systemic pressure and subsequent dilation can lead to reoperation. Inherent material property differences between pulmonary and aortic roots may influence remodeling but are currently unknown. The objective of this study was to determine...

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Veröffentlicht in:The Annals of thoracic surgery 2010-06, Vol.89 (6), p.1981-1988
Hauptverfasser: Matthews, Peter B., BS, Azadani, Ali N., PhD, Jhun, Choon-Sik, PhD, Ge, Liang, PhD, Guy, T. Sloane, MD, Guccione, Julius M., PhD, Tseng, Elaine E., MD
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container_end_page 1988
container_issue 6
container_start_page 1981
container_title The Annals of thoracic surgery
container_volume 89
creator Matthews, Peter B., BS
Azadani, Ali N., PhD
Jhun, Choon-Sik, PhD
Ge, Liang, PhD
Guy, T. Sloane, MD
Guccione, Julius M., PhD
Tseng, Elaine E., MD
description Background The pulmonary autograft remodels when subjected to systemic pressure and subsequent dilation can lead to reoperation. Inherent material property differences between pulmonary and aortic roots may influence remodeling but are currently unknown. The objective of this study was to determine stiffness across a wide range of strain and compare nonlinear material properties of corresponding regions of native aortic and pulmonary roots. Methods Tissue samples from porcine aortic and pulmonary roots—sinuses and supravalvular artery distal to the sinotubular junction—were subjected to displacement-controlled equibiaxial stretch testing. Stress-strain data recorded were used to derive strain energy functions for each region. Stiffness from low to high strains at 0.15, 0.3, and 0.5 strain were determined for comparisons. Results Aortic and pulmonary roots exhibited qualitatively similar material properties; both had greater nonlinearity in the sinus than supravalvular artery. The pulmonary artery was significantly more compliant than the ascending aorta both circumferentially and longitudinally throughout the strain range ( p < 0.03), except at high strain circumferentially ( p = 0.06). However, no differences in stiffness were seen circumferentially or longitudinally between pulmonary and aortic sinuses ( p ≥ 0.3) until high strain, when the pulmonary sinuses were significantly stiffer ( p < 0.05) in both directions. Conclusions Differences in stiffness between porcine aortic and pulmonary roots are regionally specific, supravalvular artery versus sinus. These regional differences may impact the mode of remodeling to influence late autograft dilation.
doi_str_mv 10.1016/j.athoracsur.2010.03.002
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Sloane, MD ; Guccione, Julius M., PhD ; Tseng, Elaine E., MD</creator><creatorcontrib>Matthews, Peter B., BS ; Azadani, Ali N., PhD ; Jhun, Choon-Sik, PhD ; Ge, Liang, PhD ; Guy, T. Sloane, MD ; Guccione, Julius M., PhD ; Tseng, Elaine E., MD</creatorcontrib><description>Background The pulmonary autograft remodels when subjected to systemic pressure and subsequent dilation can lead to reoperation. Inherent material property differences between pulmonary and aortic roots may influence remodeling but are currently unknown. The objective of this study was to determine stiffness across a wide range of strain and compare nonlinear material properties of corresponding regions of native aortic and pulmonary roots. Methods Tissue samples from porcine aortic and pulmonary roots—sinuses and supravalvular artery distal to the sinotubular junction—were subjected to displacement-controlled equibiaxial stretch testing. Stress-strain data recorded were used to derive strain energy functions for each region. Stiffness from low to high strains at 0.15, 0.3, and 0.5 strain were determined for comparisons. Results Aortic and pulmonary roots exhibited qualitatively similar material properties; both had greater nonlinearity in the sinus than supravalvular artery. The pulmonary artery was significantly more compliant than the ascending aorta both circumferentially and longitudinally throughout the strain range ( p &lt; 0.03), except at high strain circumferentially ( p = 0.06). However, no differences in stiffness were seen circumferentially or longitudinally between pulmonary and aortic sinuses ( p ≥ 0.3) until high strain, when the pulmonary sinuses were significantly stiffer ( p &lt; 0.05) in both directions. Conclusions Differences in stiffness between porcine aortic and pulmonary roots are regionally specific, supravalvular artery versus sinus. These regional differences may impact the mode of remodeling to influence late autograft dilation.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2010.03.002</identifier><identifier>PMID: 20494060</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Aorta - transplantation ; Biomechanical Phenomena ; Cardiothoracic Surgery ; Humans ; Pulmonary Artery - transplantation ; Surgery ; Swine</subject><ispartof>The Annals of thoracic surgery, 2010-06, Vol.89 (6), p.1981-1988</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2010 The Society of Thoracic Surgeons</rights><rights>2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. 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Sloane, MD</creatorcontrib><creatorcontrib>Guccione, Julius M., PhD</creatorcontrib><creatorcontrib>Tseng, Elaine E., MD</creatorcontrib><title>Comparison of Porcine Pulmonary and Aortic Root Material Properties</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background The pulmonary autograft remodels when subjected to systemic pressure and subsequent dilation can lead to reoperation. Inherent material property differences between pulmonary and aortic roots may influence remodeling but are currently unknown. The objective of this study was to determine stiffness across a wide range of strain and compare nonlinear material properties of corresponding regions of native aortic and pulmonary roots. Methods Tissue samples from porcine aortic and pulmonary roots—sinuses and supravalvular artery distal to the sinotubular junction—were subjected to displacement-controlled equibiaxial stretch testing. Stress-strain data recorded were used to derive strain energy functions for each region. Stiffness from low to high strains at 0.15, 0.3, and 0.5 strain were determined for comparisons. Results Aortic and pulmonary roots exhibited qualitatively similar material properties; both had greater nonlinearity in the sinus than supravalvular artery. The pulmonary artery was significantly more compliant than the ascending aorta both circumferentially and longitudinally throughout the strain range ( p &lt; 0.03), except at high strain circumferentially ( p = 0.06). However, no differences in stiffness were seen circumferentially or longitudinally between pulmonary and aortic sinuses ( p ≥ 0.3) until high strain, when the pulmonary sinuses were significantly stiffer ( p &lt; 0.05) in both directions. Conclusions Differences in stiffness between porcine aortic and pulmonary roots are regionally specific, supravalvular artery versus sinus. These regional differences may impact the mode of remodeling to influence late autograft dilation.</description><subject>Animals</subject><subject>Aorta - transplantation</subject><subject>Biomechanical Phenomena</subject><subject>Cardiothoracic Surgery</subject><subject>Humans</subject><subject>Pulmonary Artery - transplantation</subject><subject>Surgery</subject><subject>Swine</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq0KVBbav1D5xinbsR17kwsSrApFomIFVOrNcpyx6iWJFzupxL_H0dIiceppvt6Z0TxDCGWwZMDU1-3SjL9DNDZNcckhp0EsAfgHsmBS8kJxWR-QBQCIoqxX8ogcp7TNIc_lj-SIQ1mXoGBB1uvQ70z0KQw0OLoJ0foB6Wbq-jCY-EzN0NLzEEdv6V0II_1hRozedHQTww5zHtMncuhMl_Dzqz0hPy-_Pay_Fze3V9fr85vClrwaC2fa1ppKOpS8schVi0Y6qVTTsBqFzAVEJxRi5ZQDJmRluFFN7awoOa_ECTndz93F8DRhGnXvk8WuMwOGKemVEKIs2WpWVnuljSGliE7vou_zOZqBngnqrX4jqGeCGoTOfHLrl9clU9Nj-6_xL7IsuNgLMJ_6x2PUyXocLLY-oh11G_z_bDl7N8R2fvDWdI_4jGkbpjhklJrpxDXo-_mT8yNZdsoafokXM7uddA</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Matthews, Peter B., BS</creator><creator>Azadani, Ali N., PhD</creator><creator>Jhun, Choon-Sik, PhD</creator><creator>Ge, Liang, PhD</creator><creator>Guy, T. Sloane, MD</creator><creator>Guccione, Julius M., PhD</creator><creator>Tseng, Elaine E., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Comparison of Porcine Pulmonary and Aortic Root Material Properties</title><author>Matthews, Peter B., BS ; Azadani, Ali N., PhD ; Jhun, Choon-Sik, PhD ; Ge, Liang, PhD ; Guy, T. Sloane, MD ; Guccione, Julius M., PhD ; Tseng, Elaine E., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-faddca85fe52bce26dea5f566bb19e355feeef36ee8f6f01358a2a6b9fc342283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Aorta - transplantation</topic><topic>Biomechanical Phenomena</topic><topic>Cardiothoracic Surgery</topic><topic>Humans</topic><topic>Pulmonary Artery - transplantation</topic><topic>Surgery</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matthews, Peter B., BS</creatorcontrib><creatorcontrib>Azadani, Ali N., PhD</creatorcontrib><creatorcontrib>Jhun, Choon-Sik, PhD</creatorcontrib><creatorcontrib>Ge, Liang, PhD</creatorcontrib><creatorcontrib>Guy, T. Sloane, MD</creatorcontrib><creatorcontrib>Guccione, Julius M., PhD</creatorcontrib><creatorcontrib>Tseng, Elaine E., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matthews, Peter B., BS</au><au>Azadani, Ali N., PhD</au><au>Jhun, Choon-Sik, PhD</au><au>Ge, Liang, PhD</au><au>Guy, T. Sloane, MD</au><au>Guccione, Julius M., PhD</au><au>Tseng, Elaine E., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Porcine Pulmonary and Aortic Root Material Properties</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>89</volume><issue>6</issue><spage>1981</spage><epage>1988</epage><pages>1981-1988</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Background The pulmonary autograft remodels when subjected to systemic pressure and subsequent dilation can lead to reoperation. Inherent material property differences between pulmonary and aortic roots may influence remodeling but are currently unknown. The objective of this study was to determine stiffness across a wide range of strain and compare nonlinear material properties of corresponding regions of native aortic and pulmonary roots. Methods Tissue samples from porcine aortic and pulmonary roots—sinuses and supravalvular artery distal to the sinotubular junction—were subjected to displacement-controlled equibiaxial stretch testing. Stress-strain data recorded were used to derive strain energy functions for each region. Stiffness from low to high strains at 0.15, 0.3, and 0.5 strain were determined for comparisons. Results Aortic and pulmonary roots exhibited qualitatively similar material properties; both had greater nonlinearity in the sinus than supravalvular artery. The pulmonary artery was significantly more compliant than the ascending aorta both circumferentially and longitudinally throughout the strain range ( p &lt; 0.03), except at high strain circumferentially ( p = 0.06). However, no differences in stiffness were seen circumferentially or longitudinally between pulmonary and aortic sinuses ( p ≥ 0.3) until high strain, when the pulmonary sinuses were significantly stiffer ( p &lt; 0.05) in both directions. Conclusions Differences in stiffness between porcine aortic and pulmonary roots are regionally specific, supravalvular artery versus sinus. These regional differences may impact the mode of remodeling to influence late autograft dilation.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>20494060</pmid><doi>10.1016/j.athoracsur.2010.03.002</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Animals
Aorta - transplantation
Biomechanical Phenomena
Cardiothoracic Surgery
Humans
Pulmonary Artery - transplantation
Surgery
Swine
title Comparison of Porcine Pulmonary and Aortic Root Material Properties
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