Clinical outcomes of patients with anterior segment neovascularization treated with or without intraocular bevacizumab

Introduction The purpose of this study was to evaluate the clinical outcomes of patients with anterior segment neovascularization treated with or without intravitreal bevacizumab. Methods This was a retrospective, comparative case series of 60 patients with anterior segment neovascularization: 30 consecutive patients treated with intravitreal bevacizumab and 30 age-, gender-, and race-matched controls treated without bevacizumab. Results The mean follow-up time was 9.1±6.3 months in the bevacizumab group and 8.6±6.2 months in the control group ( P =0.769). At baseline, no significant difference was observed in initial visual acuity, intraocular pressure, gonioscopy, and iris or angle neovascularization ( P =0.179, 0.432, 0.065, and 0.966, respectively). At the final examination, no significant difference was observed in mean intraocular pressure ( P =0.464), mean number of glaucoma medications ( P =1.00), or presence of anterior segment neovascularization ( P =0.699). Final visual acuity better than 20/60 was achieved in six patients in the bevacizumab group and none in the control group ( P =0.013). Comparison of linear regressions of baseline and final visual acuity (LogMAR) showed a significant difference between the two groups ( P =0.040). In the bevacizumab group, 18 patients required glaucoma surgery, whereas 30 patients in the control group required surgery ( P