Cross-Coupling Reactions through the Intramolecular Activation of Alkyl(triorgano)silanes

Cross-Coupling Reactions through the Intramolecular Activation of Alkyl(triorgano)silanes

Cross‐Si‐ing the Jordan: Cross‐coupling reactions of 2‐(2‐hydroxyprop‐2‐yl)phenyl‐substituted alkylsilanes with a variety of aryl halides proceed in the presence of palladium and copper catalysts. The use of K3PO4 base allows for highly chemoselective alkyl coupling with both primary and secondary a...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-06, Vol.49 (26), p.4447-4450
Hauptverfasser: Nakao, Yoshiaki, Takeda, Masahide, Matsumoto, Takuya, Hiyama, Tamejiro
Format: Artikel
Sprache:eng
Schlagworte:
copper
cross-coupling
palladium
silicon
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Zusammenfassung:Cross‐Si‐ing the Jordan: Cross‐coupling reactions of 2‐(2‐hydroxyprop‐2‐yl)phenyl‐substituted alkylsilanes with a variety of aryl halides proceed in the presence of palladium and copper catalysts. The use of K3PO4 base allows for highly chemoselective alkyl coupling with both primary and secondary alkyl groups (Alk).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000816