Enantioselective Synthesis of (−)-Englerins A and B

Enantioselective Synthesis of (−)-Englerins A and B

All that glitters is gold: The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold‐catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2010-05, Vol.49 (20), p.3517-3519
Hauptverfasser: Molawi, Kian, Delpont, Nicolas, Echavarren, Antonio M.
Format: Artikel
Sprache:eng
Schlagworte:
Allyl Compounds - chemistry
antitumor agents
Catalysis
Cyclization
domino processes
Gold - chemistry
gold catalysis
guaiane sesquiterpenes
Models, Molecular
Molecular Structure
Sesquiterpenes, Guaiane - chemical synthesis
Stereoisomerism
total synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:All that glitters is gold: The total synthesis of the natural enantiomers of englerins A and B has been completed using a gold‐catalyzed stereoselective domino alkyne/alkene/carbonyl cyclization of an enyne with an unprotected alcohol group at a stereogenic allylic position (see scheme; TES=triethylsilyl).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000890