Regulatory Effect of Histamine on the Barrier Function of Intestinal Mucosal

Objectives To investigate the regulatory effect of histamine on the barrier function of intestinal mucosal. Methods The monolayer Caco-2 cell system in vitro and the model of hemorrhage infection in rats in vivo were established as experimental models. The amount of bacterial translocation was taken...

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Veröffentlicht in:	Journal of gastrointestinal surgery 2010-07, Vol.14 (7), p.1180-1185
Hauptverfasser:	Duan, Ligeng, Chen, Xiaoli, Alexander, J. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections - physiopathology Bacterial Translocation Caco-2 Cells Cimetidine - pharmacology Gastroenterology Gastrointestinal Hemorrhage - physiopathology Hemorrhage Histamine Histamine - pharmacology Histamine - physiology Humans Infections Intestinal Mucosa - physiology Medicine Medicine & Public Health Original Article Rats Rats, Sprague-Dawley Rodents Surgery
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Zusammenfassung:	Objectives To investigate the regulatory effect of histamine on the barrier function of intestinal mucosal. Methods The monolayer Caco-2 cell system in vitro and the model of hemorrhage infection in rats in vivo were established as experimental models. The amount of bacterial translocation was taken as an index of the effect of histamine and its receptor antagon, cimetidine on the intestinal mucosal barrier function. Results (1) The in vitro experiment showed that after treatment with histamine, the CFU of Escherichia coli 075 invading into Caco-2 cells were much lower than that in the control group ( P
ISSN:	1091-255X 1873-4626
DOI:	10.1007/s11605-010-1208-9