Answer to the “Comment on functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse” by Stefan Bittner et al. [Immunol. Lett. 125 (Aug 15 (2)) (2009) 156–157]

Abstract A critical comment to our paper on Kv1.3 channels in the immunological synapse (IS) was published, which emphasized the role of two-pore potassium channels (TASK-1 and 3) in the physiology of T lymphocytes [1] . Here we provide several lines of evidence that presence of TASK channels in the...

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Veröffentlicht in:	Immunology letters 2010-03, Vol.129 (1), p.47-49
Hauptverfasser:	Hajdú, Péter, Szilágyi, Orsolya, Tóth, Ágnes, Krasznai, Zoltán, Pocsai, Krisztina, Panyi, György
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Electrophysiological Phenomena Immunological synapse Immunological Synapses - metabolism Kv1.3 Kv1.3 Potassium Channel - immunology Kv1.3 Potassium Channel - metabolism Lymphocyte Activation - drug effects Mice Potassium Channel Blockers - pharmacology Potassium Channels, Tandem Pore Domain - immunology Potassium Channels, Tandem Pore Domain - metabolism Scorpion Venoms - pharmacology TASK channels Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology
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Zusammenfassung:	Abstract A critical comment to our paper on Kv1.3 channels in the immunological synapse (IS) was published, which emphasized the role of two-pore potassium channels (TASK-1 and 3) in the physiology of T lymphocytes [1] . Here we provide several lines of evidence that presence of TASK channels in the T cell line (a murine Th2 Cell line, D10) used in our experimental model cannot explain the changes in the biophysical parameters of the whole-cell current upon formation of an IS [2].
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2009.12.026