Preparation and antimicrobial behaviour of gemini fluorosurfactants

The introduction of perfluorinated chains in the molecular structure of quaternary ammonium gemini surfactants have led to particularly active antimicrobial agents evaluated in this work. Connectors and spacers were studied in relation with antimicrobial activity in order to determine which molecula...

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Veröffentlicht in:	European journal of medicinal chemistry 2003-05, Vol.38 (5), p.519-523
Hauptverfasser:	Massi, Lionel, Guittard, Frédéric, Levy, Richard, Duccini, Yves, Géribaldi, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antimicrobial agents Aspergillus niger - drug effects Bacteriostatic Biological and medical sciences Candida albicans - drug effects Fluorinated surfactants Geminis Hydrocarbons, Fluorinated - chemistry Hydrocarbons, Fluorinated - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa - drug effects Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Staphylococcus aureus - drug effects Structure-Activity Relationship Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Surfactants
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Beschreibung
Zusammenfassung:	The introduction of perfluorinated chains in the molecular structure of quaternary ammonium gemini surfactants have led to particularly active antimicrobial agents evaluated in this work. Connectors and spacers were studied in relation with antimicrobial activity in order to determine which molecular parameters are ‘critical’ for biological activity.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/S0223-5234(03)00059-X