Adding new chemistries to the genetic code

Adding new chemistries to the genetic code

The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonic...

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Veröffentlicht in:Annual review of biochemistry 2010-01, Vol.79 (1), p.413-444
Hauptverfasser: Liu, Chang C, Schultz, Peter G
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Amino Acids - chemistry
Amino Acyl-tRNA Synthetases - chemistry
Animals
Biochemistry
E coli
Escherichia coli - chemistry
Escherichia coli - genetics
Escherichia coli - metabolism
Genetic Code
Genetics
Protein Engineering
Proteins
RNA, Transfer - chemistry
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Transfer RNA
Yeasts
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Beschreibung
Zusammenfassung:The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonical 20 amino acids and thus provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.biochem.052308.105824