MMP-13 selective isonipecotamide α-sulfone hydroxamates
N-Aryl isonipecotamide α-sulfone hydroxamates have been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (12), p.3561-3564 |
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| container_end_page | 3564 |
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| container_issue | 12 |
| container_start_page | 3561 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 20 |
| creator | Kolodziej, Stephen A. Hockerman, Susan L. DeCrescenzo, Gary A. McDonald, Joseph J. Mischke, Debbie A. Munie, Grace E. Fletcher, Theresa R. Stehle, Nathan Swearingen, Craig Becker, Daniel P. |
| description | N-Aryl isonipecotamide α-sulfone hydroxamates have been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. |
| doi_str_mv | 10.1016/j.bmcl.2010.04.111 |
| format | Article |
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A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2010.04.111</identifier><identifier>PMID: 20529685</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Administration, Oral ; Amides ; Animals ; Antineoplastic agents ; Biological and medical sciences ; General aspects ; Hydroxamate ; Hydroxamic Acids - chemical synthesis ; Hydroxamic Acids - chemistry ; Hydroxamic Acids - pharmacology ; Inhibitory Concentration 50 ; Matrix metalloproteinase inhibitor ; Matrix Metalloproteinase Inhibitors ; Medical sciences ; Metalloenzyme ; MMP inhibitor ; MMP-13 selective ; Pharmacology. Drug treatments ; Rats ; Small Molecule Libraries ; Solubility ; Substrate Specificity ; Sulfones</subject><ispartof>Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3561-3564</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-58ad09b1ac792305abbd938e954ad4493225829f369f92686532627dc93843ab3</citedby><cites>FETCH-LOGICAL-c385t-58ad09b1ac792305abbd938e954ad4493225829f369f92686532627dc93843ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X10005895$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22902432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20529685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolodziej, Stephen A.</creatorcontrib><creatorcontrib>Hockerman, Susan L.</creatorcontrib><creatorcontrib>DeCrescenzo, Gary A.</creatorcontrib><creatorcontrib>McDonald, Joseph J.</creatorcontrib><creatorcontrib>Mischke, Debbie A.</creatorcontrib><creatorcontrib>Munie, Grace E.</creatorcontrib><creatorcontrib>Fletcher, Theresa R.</creatorcontrib><creatorcontrib>Stehle, Nathan</creatorcontrib><creatorcontrib>Swearingen, Craig</creatorcontrib><creatorcontrib>Becker, Daniel P.</creatorcontrib><title>MMP-13 selective isonipecotamide α-sulfone hydroxamates</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>N-Aryl isonipecotamide α-sulfone hydroxamates have been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.</description><subject>Administration, Oral</subject><subject>Amides</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>General aspects</subject><subject>Hydroxamate</subject><subject>Hydroxamic Acids - chemical synthesis</subject><subject>Hydroxamic Acids - chemistry</subject><subject>Hydroxamic Acids - pharmacology</subject><subject>Inhibitory Concentration 50</subject><subject>Matrix metalloproteinase inhibitor</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Medical sciences</subject><subject>Metalloenzyme</subject><subject>MMP inhibitor</subject><subject>MMP-13 selective</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Small Molecule Libraries</subject><subject>Solubility</subject><subject>Substrate Specificity</subject><subject>Sulfones</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotlZfwIV0I65mzHU6ATdSvEGLLhTchUxyBlPmUpOZYh_LF_GZTGnVnasDh-__z-FD6JTglGCSXS7SojZVSnFcYJ4SQvbQkPCMJ4xjsY-GWGY4ySV_HaCjEBYYE445P0QDigWVWS6GKJ_PnxLCxgEqMJ1bwdiFtnFLMG2na2dh_PWZhL4q2wbGb2vr2w9d6w7CMToodRXgZDdH6OX25nl6n8we7x6m17PEsFx0ici1xbIg2kwkZVjoorCS5SAF15ZzySgVOZUly2QpaZZngtGMTqyJEGe6YCN0se1d-va9h9Cp2gUDVaUbaPugJoxRMaESR5JuSePbEDyUauldrf1aEaw2wtRCbYSpjTCFuYrCYuhsV98XNdjfyI-hCJzvAB2MrkqvG-PCHxcvU85o5K62HEQZKwdeBeOgMWCdj2aVbd1_f3wDBfSHuA</recordid><startdate>20100615</startdate><enddate>20100615</enddate><creator>Kolodziej, Stephen A.</creator><creator>Hockerman, Susan L.</creator><creator>DeCrescenzo, Gary A.</creator><creator>McDonald, Joseph J.</creator><creator>Mischke, Debbie A.</creator><creator>Munie, Grace E.</creator><creator>Fletcher, Theresa R.</creator><creator>Stehle, Nathan</creator><creator>Swearingen, Craig</creator><creator>Becker, Daniel P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100615</creationdate><title>MMP-13 selective isonipecotamide α-sulfone hydroxamates</title><author>Kolodziej, Stephen A. ; Hockerman, Susan L. ; DeCrescenzo, Gary A. ; McDonald, Joseph J. ; Mischke, Debbie A. ; Munie, Grace E. ; Fletcher, Theresa R. ; Stehle, Nathan ; Swearingen, Craig ; Becker, Daniel P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-58ad09b1ac792305abbd938e954ad4493225829f369f92686532627dc93843ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Amides</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>General aspects</topic><topic>Hydroxamate</topic><topic>Hydroxamic Acids - chemical synthesis</topic><topic>Hydroxamic Acids - chemistry</topic><topic>Hydroxamic Acids - pharmacology</topic><topic>Inhibitory Concentration 50</topic><topic>Matrix metalloproteinase inhibitor</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Medical sciences</topic><topic>Metalloenzyme</topic><topic>MMP inhibitor</topic><topic>MMP-13 selective</topic><topic>Pharmacology. 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| ispartof | Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3561-3564 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Amides Animals Antineoplastic agents Biological and medical sciences General aspects Hydroxamate Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Inhibitory Concentration 50 Matrix metalloproteinase inhibitor Matrix Metalloproteinase Inhibitors Medical sciences Metalloenzyme MMP inhibitor MMP-13 selective Pharmacology. Drug treatments Rats Small Molecule Libraries Solubility Substrate Specificity Sulfones |
| title | MMP-13 selective isonipecotamide α-sulfone hydroxamates |
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