MMP-13 selective isonipecotamide α-sulfone hydroxamates

N-Aryl isonipecotamide α-sulfone hydroxamates have been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (12), p.3561-3564
Hauptverfasser:	Kolodziej, Stephen A., Hockerman, Susan L., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Stehle, Nathan, Swearingen, Craig, Becker, Daniel P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amides Animals Antineoplastic agents Biological and medical sciences General aspects Hydroxamate Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Inhibitory Concentration 50 Matrix metalloproteinase inhibitor Matrix Metalloproteinase Inhibitors Medical sciences Metalloenzyme MMP inhibitor MMP-13 selective Pharmacology. Drug treatments Rats Small Molecule Libraries Solubility Substrate Specificity Sulfones
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Zusammenfassung:	N-Aryl isonipecotamide α-sulfone hydroxamates have been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.04.111