Brominated Polyacetylenic Acids from the Marine Sponge Xestospongia muta: Inhibitors of HIV Protease

The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first kn...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1992-09, Vol.55 (9), p.1170-1177
Hauptverfasser:	Patil, Ashok D, Kokke, Wilhelmus C, Cochran, Sally, Francis, Terry A, Tomszek, Thaddeus, Westley, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Biological and medical sciences Boron Compounds - isolation & purification Boron Compounds - pharmacology Cells, Cultured Fatty Acids, Unsaturated - isolation & purification Fatty Acids, Unsaturated - pharmacology Freeze Drying General pharmacology HIV Protease Inhibitors - isolation & purification HIV Protease Inhibitors - pharmacology Humans L-Lactate Dehydrogenase - metabolism Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Rabbits Tissue Extracts - pharmacology
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Zusammenfassung:	The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first known examples that have been shown to inhibit HIV protease, a critical enzyme in the replication of human immunodeficiency virus.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50087a002