Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer

Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer

Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neogly...

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Veröffentlicht in:Organic & biomolecular chemistry 2010-03, Vol.8 (6), p.1351-1360
Hauptverfasser: Richardson, Jonathan P, Chan, Chung-Hei, Blanc, Javier, Saadi, Mona, Macmillan, Derek
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Biomimetic Materials - chemical synthesis
Biomimetic Materials - chemistry
Glycopeptides - chemistry
Glycoproteins - chemistry
Models, Molecular
Molecular Sequence Data
Nitrogen - chemistry
Oligosaccharides - chemistry
Protein Conformation
Substrate Specificity
Sulfur - chemistry
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Zusammenfassung:Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
ISSN:1477-0520
1477-0539
DOI:10.1039/b920535g