Genetics of Hypertension: The Adducin Paradigm

: The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-04, Vol.986 (1), p.660-668
Hauptverfasser:	BIANCHI, GIUSEPPE, TRIPODI, GRAZIA
Format:	Artikel
Sprache:	eng
Schlagworte:	adducin Animals Calmodulin-Binding Proteins - genetics Chromosome Mapping Cytoskeletal Proteins - genetics Disease Models, Animal endocytosis genetics Humans hypertension Hypertension - genetics Hypertension, Renal - genetics Na-K pump Rats tubular renal reabsorption
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Beschreibung
Zusammenfassung:	: The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na‐K pump; and (4) future directions.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2003.tb07280.x