Lesion-Induced Sprouting in the Rat Dentate Gyrus is Inhibited by Repeated Ethanol Administration

The effect of ethanol on hippocampal axonal sprouting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcholinesterase staining in the outer molecular layer and a conc...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1982-11, Vol.218 (4574), p.808-810
Hauptverfasser: West, James R., Lind, Marcia D., Demuth, Ronald M., Parker, Elizabeth S., Alkana, Ronald L., Cassell, Martin, Black, Asa C.
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Sprache:eng
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Zusammenfassung:The effect of ethanol on hippocampal axonal sprouting was studied with a histochemical technique for identifying acetylcholinesterase. Unilateral lesion of the entorhinal cortex in adult rats produced an increase in the density of acetylcholinesterase staining in the outer molecular layer and a concomitant increase in the width of the pale-staining commissural-associational zone of the dentate gyrus. Other rats were given ethanol (11.3 $\pm $ 0.45 grams per kilogram) for 2 weeks before and 9 days after receiving the lesion. Ethanol abolished the expansion of the commissural-associational zone. The effect of ethanol on sprouting axons suggests that it may inhibit recovery of function after brain injury.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.218.4574.808