LACTIMIDOMYCIN, A NEW GLUTARIMIDE GROUP ANTIBIOTIC: PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic...

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Veröffentlicht in:	Journal of antibiotics 1992/09/25, Vol.45(9), pp.1433-1441
Hauptverfasser:	SUGAWARA, KOKO, NISHIYAMA, YUJI, TODA, SOICHIRO, KOMIYAMA, NOBUJIRO, HATORI, MASAMI, MORIYAMA, TOSHIO, SAWADA, YOSUKE, KAMEI, HIDEO, KONISHI, MASATAKA, OKI, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Biotechnology & Applied Microbiology Chemotherapic agents Female Fundamental and applied biological sciences. Psychology Immunology Life Sciences & Biomedicine Macrolides Magnetic Resonance Spectroscopy Male Mice Microbial Sensitivity Tests Microbiology Neoplasms, Experimental - drug therapy Pharmacology & Pharmacy Piperidones - chemistry Piperidones - isolation & purification Piperidones - pharmacology Science & Technology Streptomyces - chemistry
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Zusammenfassung:	Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.1433