Osmium-Catalyzed 7-endo Heterocyclization of Aromatic Alkynols into Benzoxepines

Osmium-Catalyzed 7-endo Heterocyclization of Aromatic Alkynols into Benzoxepines

The wizard of Os: Regioselective osmium‐catalyzed 7‐endo heterocyclization of aromatic alkynols affords benzoxepines in good yields. The proposed catalytic cycle involves the key formation of osmium–vinylidene complexes via an alkynyl‐hydride–osmium(IV) complex from the starting alkynol.

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Veröffentlicht in:Angewandte Chemie (International ed.) 2010-06, Vol.49 (25), p.4278-4281
Hauptverfasser: Varela-Fernández, Alejandro, García-Yebra, Cristina, Varela, Jesús A, Esteruelas, Miguel A, Saá, Carlos
Format: Artikel
Sprache:eng
Schlagworte:
alkynols
benzoxepines
cyclization
heterocycles
osmium
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Zusammenfassung:The wizard of Os: Regioselective osmium‐catalyzed 7‐endo heterocyclization of aromatic alkynols affords benzoxepines in good yields. The proposed catalytic cycle involves the key formation of osmium–vinylidene complexes via an alkynyl‐hydride–osmium(IV) complex from the starting alkynol.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201000455