Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation

We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAFII130, thereby repressi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2003-06, Vol.125 (22), p.6612-6613
Hauptverfasser:	Lamarre-Vincent, Nathan, Hsieh-Wilson, Linda C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Acetylglucosamine - metabolism Analytical chemistry Animals Brain - metabolism Brain - physiology Chemistry Cyclic AMP Response Element-Binding Protein - metabolism Cyclic AMP Response Element-Binding Protein - physiology Exact sciences and technology Gene Expression Regulation - physiology Glycosylation HeLa Cells Humans Miscellaneous N-Acetyllactosamine Synthase - chemistry N-Acetyllactosamine Synthase - metabolism Rats Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization TATA-Binding Protein Associated Factors - metabolism TATA-Binding Protein Associated Factors - physiology Transcription Factor TFIID - metabolism Transcription Factor TFIID - physiology Transcriptional Activation - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!