Design and biological evaluation of biphenyl-4-carboxylic acid hydrazide-hydrazone for antimicrobial activity

Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli an...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2010-05, Vol.67 (3), p.255-259
Hauptverfasser:	Deep, Aakash, Jain, Sandeep, Sharma, Prabodh Chander, Verma, Prabhakar, Kumar, Mahesh, Dora, Chander Parkash
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Bacteria - drug effects Bacteria - growth & development Biphenyl Compounds - chemical synthesis Biphenyl Compounds - pharmacology Carboxylic Acids - chemical synthesis Carboxylic Acids - pharmacology Chromatography, Thin Layer Drug Design Fungi - drug effects Fungi - growth & development Hydrazines - chemical synthesis Hydrazines - pharmacology Hydrazones - chemical synthesis Hydrazones - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure Spectroscopy, Fourier Transform Infrared Structure-Activity Relationship
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Zusammenfassung:	Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger All newly synthesized compounds exhibited promising results.
ISSN:	0001-6837