Homograft Rabbit Skin Protection by Phenothiazine Derivatives

Homograft Rabbit Skin Protection by Phenothiazine Derivatives

Rejection of homografts of rabbit skin can be delayed by treatment with either chlorpromazine, perphenazine, or promethazine. Promethazine can also delay rejection of second-set homografts. The membrane protective action of these phenothiazine derivatives appears to be the most likely mechanism of t...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-06, Vol.148 (3676), p.1468-1469
Hauptverfasser: Eyal, Zwi, Warwick, Warren J., Mayo, Charles H., Lillehei, Richard C.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antigens
Graft rejection
Homologous transplantation
Skin grafts
Transplantation immunology
Zines
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Zusammenfassung:Rejection of homografts of rabbit skin can be delayed by treatment with either chlorpromazine, perphenazine, or promethazine. Promethazine can also delay rejection of second-set homografts. The membrane protective action of these phenothiazine derivatives appears to be the most likely mechanism of this activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.148.3676.1468