Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pr...

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Veröffentlicht in:	European journal of pharmacology 1992-08, Vol.219 (2), p.345-346
Hauptverfasser:	Menkens, Kent, Bilsky, Edward J., Wild, Kenneth D., Portoghese, Philip S., Reid, Larry D., Porreca, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cocaine Cocaine - pharmacology Conditioning, Operant - drug effects Drug addictions Indoles - pharmacology Male Medical sciences Morphinans - pharmacology Naltrexone - analogs & derivatives Naltrindole Narcotic Antagonists - pharmacology Place preference Rats Rats, Inbred Lew Toxicology
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Beschreibung
Zusammenfassung:	Naltrindole, a selective δ-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90319-Y