Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests. A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-06, Vol.20 (12), p.3521-3525
Hauptverfasser:	Cho, Tang Peng, Gang, Lin Zhi, Long, Yang Fang, Yang, Wang, Qian, Wang, Lei, Zhang, Jing, Luo Jing, Ying, Feng, Ke, Yan Pang, Ying, Leng, Jun, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bicyclo[3.3.0]octane derivatives Biological and medical sciences Bridged Bicyclo Compounds - chemical synthesis Bridged Bicyclo Compounds - pharmacology Diabetes Mellitus, Type 2 - drug therapy Dipeptidyl peptidase 4 Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis Dipeptidyl-Peptidase IV Inhibitors - pharmacology Dose-Response Relationship, Drug General and cellular metabolism. Vitamins Glucose Tolerance Test Inhibitors Medical sciences Mice Mice, Inbred Strains Octanes - chemical synthesis Octanes - pharmacology Oral glucose tolerance tests Pharmacology. Drug treatments Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests. A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.04.138