Influence of d(+)-glucosamine on infection rates and parasite loads in tsetse flies ( Glossina spp.) infected with Trypanosoma brucei
Teneral Glossina morsitans centralis, G. m. morsitans and G. pallidipes were infected with three different clones of Trypanosoma brucei in blood containing d(+)-glucosamine, an inhibitor of tsetse midgut lectin. On average, 5 days of d(+)-glucosamine treatment tripled infection rates, without affect...
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| Veröffentlicht in: | Acta tropica 1992-08, Vol.51 (3), p.217-228 |
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| creator | Mihok, Steve Otieno, Leonard H. Darji, Nafisa Munyinyi, David |
| description | Teneral
Glossina morsitans centralis, G. m. morsitans and
G. pallidipes were infected with three different clones of
Trypanosoma brucei in blood containing
d(+)-glucosamine, an inhibitor of tsetse midgut lectin. On average, 5 days of
d(+)-glucosamine treatment tripled infection rates, without affecting the proportion of infections that matured. Total infection rates were equal in males and females, but twice as many infections matured in males. Counts of parasites in the guts and salivary glands of 277 flies revealed order of magnitude differences among flies, with females consistently having 2–3-times as many parasites as males. Parasite numbers varied in a sex-specific manner among tsetse-clone combinations, but these differences were not correlated with similar large differences in infection rates.
d(+)-glucosamine treatment had no significant effect on parasite loads. |
| doi_str_mv | 10.1016/0001-706X(92)90040-5 |
| format | Article |
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Glossina morsitans centralis, G. m. morsitans and
G. pallidipes were infected with three different clones of
Trypanosoma brucei in blood containing
d(+)-glucosamine, an inhibitor of tsetse midgut lectin. On average, 5 days of
d(+)-glucosamine treatment tripled infection rates, without affecting the proportion of infections that matured. Total infection rates were equal in males and females, but twice as many infections matured in males. Counts of parasites in the guts and salivary glands of 277 flies revealed order of magnitude differences among flies, with females consistently having 2–3-times as many parasites as males. Parasite numbers varied in a sex-specific manner among tsetse-clone combinations, but these differences were not correlated with similar large differences in infection rates.
d(+)-glucosamine treatment had no significant effect on parasite loads.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/0001-706X(92)90040-5</identifier><identifier>PMID: 1359749</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>2-Amino-2-deoxy- d-glucose ; Animals ; Biological and medical sciences ; d(+)-Glucosamine ; Female ; Fundamental and applied biological sciences. Psychology ; Glossina spp ; Glucosamine - pharmacology ; Infectivity ; Intestines - parasitology ; Invertebrates ; Kenya - epidemiology ; Male ; Medically important nuisances and vectors, pests of stored products and materials: population survey and control ; Midgut lectin ; Salivary Glands - parasitology ; Trypanosoma brucei ; Trypanosoma brucei brucei - drug effects ; Trypanosoma brucei brucei - growth & development ; Tsetse Flies - parasitology ; Vectorial capacity ; Vectors. Intermediate hosts</subject><ispartof>Acta tropica, 1992-08, Vol.51 (3), p.217-228</ispartof><rights>1992 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-ed4c374419d8887c631e2b9c6f83a7b4b54aea7f70f7f60b845c816259da2f713</citedby><cites>FETCH-LOGICAL-c417t-ed4c374419d8887c631e2b9c6f83a7b4b54aea7f70f7f60b845c816259da2f713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0001706X92900405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4325677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1359749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mihok, Steve</creatorcontrib><creatorcontrib>Otieno, Leonard H.</creatorcontrib><creatorcontrib>Darji, Nafisa</creatorcontrib><creatorcontrib>Munyinyi, David</creatorcontrib><title>Influence of d(+)-glucosamine on infection rates and parasite loads in tsetse flies ( Glossina spp.) infected with Trypanosoma brucei</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Teneral
Glossina morsitans centralis, G. m. morsitans and
G. pallidipes were infected with three different clones of
Trypanosoma brucei in blood containing
d(+)-glucosamine, an inhibitor of tsetse midgut lectin. On average, 5 days of
d(+)-glucosamine treatment tripled infection rates, without affecting the proportion of infections that matured. Total infection rates were equal in males and females, but twice as many infections matured in males. Counts of parasites in the guts and salivary glands of 277 flies revealed order of magnitude differences among flies, with females consistently having 2–3-times as many parasites as males. Parasite numbers varied in a sex-specific manner among tsetse-clone combinations, but these differences were not correlated with similar large differences in infection rates.
d(+)-glucosamine treatment had no significant effect on parasite loads.</description><subject>2-Amino-2-deoxy- d-glucose</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>d(+)-Glucosamine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glossina spp</subject><subject>Glucosamine - pharmacology</subject><subject>Infectivity</subject><subject>Intestines - parasitology</subject><subject>Invertebrates</subject><subject>Kenya - epidemiology</subject><subject>Male</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>Midgut lectin</subject><subject>Salivary Glands - parasitology</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma brucei brucei - drug effects</subject><subject>Trypanosoma brucei brucei - growth & development</subject><subject>Tsetse Flies - parasitology</subject><subject>Vectorial capacity</subject><subject>Vectors. Intermediate hosts</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEUxoModa2-gUIuRHaRqckkmczcFKRoLRS8qeBdOJOcaGQ2MyYzlT6A792Mu9Q7hUD-nN_5knwfIS85O-OMN-8YY7zSrPm67epdx5hklXpENrzVompqJR-TzQPylDzL-UfZ1VrVJ-SEC9Vp2W3I76vohwWjRTp66rZvd9W3YbFjhn2I5SzSED3aOZRVghkzhejoBAlymJEOI7hcEDpnLIP6IRRkSy-HMecQgeZpOtsdNdDRX2H-Tm_S3QRxzOMeaJ8Wi-E5eeJhyPjiOJ-SLx8_3Fx8qq4_X15dvL-urOR6rtBJK7SUvHNt22rbCI5139nGtwJ0L3slAUF7zbz2DetbqWzLixedg9prLk7Jm4PulMafC-bZ7EO2OAwQcVyy0UJwxTr1X1DUirVciQLKA2hT-XFCb6YU9pDuDGdmjcmsGZg1A9PV5k9MZtV_ddRf-j26v02HXEr99bEO2cLgE0Qb8gMmy_2N1gU7P2BYTLsNmEy2YQ3ThVQMN24M_37HPSuArrk</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Mihok, Steve</creator><creator>Otieno, Leonard H.</creator><creator>Darji, Nafisa</creator><creator>Munyinyi, David</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19920801</creationdate><title>Influence of d(+)-glucosamine on infection rates and parasite loads in tsetse flies ( Glossina spp.) infected with Trypanosoma brucei</title><author>Mihok, Steve ; Otieno, Leonard H. ; Darji, Nafisa ; Munyinyi, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ed4c374419d8887c631e2b9c6f83a7b4b54aea7f70f7f60b845c816259da2f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>2-Amino-2-deoxy- d-glucose</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>d(+)-Glucosamine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glossina spp</topic><topic>Glucosamine - pharmacology</topic><topic>Infectivity</topic><topic>Intestines - parasitology</topic><topic>Invertebrates</topic><topic>Kenya - epidemiology</topic><topic>Male</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>Midgut lectin</topic><topic>Salivary Glands - parasitology</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei brucei - drug effects</topic><topic>Trypanosoma brucei brucei - growth & development</topic><topic>Tsetse Flies - parasitology</topic><topic>Vectorial capacity</topic><topic>Vectors. Intermediate hosts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihok, Steve</creatorcontrib><creatorcontrib>Otieno, Leonard H.</creatorcontrib><creatorcontrib>Darji, Nafisa</creatorcontrib><creatorcontrib>Munyinyi, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihok, Steve</au><au>Otieno, Leonard H.</au><au>Darji, Nafisa</au><au>Munyinyi, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of d(+)-glucosamine on infection rates and parasite loads in tsetse flies ( Glossina spp.) infected with Trypanosoma brucei</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>51</volume><issue>3</issue><spage>217</spage><epage>228</epage><pages>217-228</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>Teneral
Glossina morsitans centralis, G. m. morsitans and
G. pallidipes were infected with three different clones of
Trypanosoma brucei in blood containing
d(+)-glucosamine, an inhibitor of tsetse midgut lectin. On average, 5 days of
d(+)-glucosamine treatment tripled infection rates, without affecting the proportion of infections that matured. Total infection rates were equal in males and females, but twice as many infections matured in males. Counts of parasites in the guts and salivary glands of 277 flies revealed order of magnitude differences among flies, with females consistently having 2–3-times as many parasites as males. Parasite numbers varied in a sex-specific manner among tsetse-clone combinations, but these differences were not correlated with similar large differences in infection rates.
d(+)-glucosamine treatment had no significant effect on parasite loads.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1359749</pmid><doi>10.1016/0001-706X(92)90040-5</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Acta tropica, 1992-08, Vol.51 (3), p.217-228 |
| issn | 0001-706X 1873-6254 |
| language | eng |
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| subjects | 2-Amino-2-deoxy- d-glucose Animals Biological and medical sciences d(+)-Glucosamine Female Fundamental and applied biological sciences. Psychology Glossina spp Glucosamine - pharmacology Infectivity Intestines - parasitology Invertebrates Kenya - epidemiology Male Medically important nuisances and vectors, pests of stored products and materials: population survey and control Midgut lectin Salivary Glands - parasitology Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - growth & development Tsetse Flies - parasitology Vectorial capacity Vectors. Intermediate hosts |
| title | Influence of d(+)-glucosamine on infection rates and parasite loads in tsetse flies ( Glossina spp.) infected with Trypanosoma brucei |
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