Antimicrobial Activity of the Dichloromethane Extract from in vitro Cultured Roots of Morinda royoc and Its Main Constituents

The dichloromethane extract and seven anthraquinones isolated from in vitro cultured roots of Morinda royoc L. were tested for their antimicrobial activity against seven yeast and seven bacterial strains. The extract showed a minimum inhibitory concentration (MIC) value of 15.6 μg/m against all spec...

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Veröffentlicht in:	Natural product communications 2010-05, Vol.5 (5), p.809-810
Hauptverfasser:	Borroto, Janetsy, Salazar, Ricardo, Pérez, Alejandro, Quiros, Yemeys, Hernandez, Martha, Waksman, Noemí, Trujillo, Reinaldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - isolation & purification Anthraquinones - pharmacology Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Candida - drug effects Cuba In Vitro Techniques Methylene Chloride - isolation & purification Methylene Chloride - pharmacology Microbial Sensitivity Tests Morinda - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry Species Specificity Staphylococcus aureus - drug effects
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Zusammenfassung:	The dichloromethane extract and seven anthraquinones isolated from in vitro cultured roots of Morinda royoc L. were tested for their antimicrobial activity against seven yeast and seven bacterial strains. The extract showed a minimum inhibitory concentration (MIC) value of 15.6 μg/m against all species of Candida tested; except C. glabrata (MIC 1.95 μg/mL), and it inhibited the growth of oxacillin-resistant Staphylococcus aureus (MIC 31.2 μg/mL). Only morindone showed activity against all yeast strains (MIC 1.9 μg/mL), and against oxacillin-resistant Staphylococcus aureus (MIC 15 μg/mL).
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1000500526