Interaction between Crystalline Penicillin and Human Plasma Proteins
Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1945-01, Vol.101 (2612), p.67-68 |
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| container_end_page | 68 |
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| container_issue | 2612 |
| container_start_page | 67 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 101 |
| creator | Chow, Bacon F. McKee, Clara M. |
| description | Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin. |
| doi_str_mv | 10.1126/science.101.2612.67 |
| format | Article |
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Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.</description><subject>Albumins</subject><subject>Alcohols</subject><subject>Antibiotics</subject><subject>Blood proteins</subject><subject>Dialysis</subject><subject>Excretion</subject><subject>Penicillin</subject><subject>Salts</subject><subject>Serum albumins</subject><subject>Sodium</subject><subject>Special Articles</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1945</creationdate><recordtype>article</recordtype><recordid>eNpFkF1LwzAYhYMobk5_gSK986o1b9Im7aXMjw0G7kKvQ5q-hYw2nUmK-O_t2GA37wfnOefiEHIPNANg4jkYi85gBhQyJoBlQl6QOdCqSCtG-SWZU8pFWlJZzMhNCDtKJ63i12QGssxpxdicvK5dRK9NtINLaoy_iC5Z-r8QdddZh8kWnTX2cCfaNclq7LVLtp0OvU62fohoXbglV63uAt6d9oJ8v799LVfp5vNjvXzZpIYXeUxz1kohZAlYNFC2AAY4a0psmGYt5kaKumykrkVbIZtmobWUVApeF7qqW8MX5OmYu_fDz4ghqt4Gg12nHQ5jUJJzyDktyonkR9L4IQSPrdp722v_p4CqQ3vq1N70gzq0p4ScXI-n_LHusTl7TnVNwMMR2IU4-LM-eaWo-D-GVHbb</recordid><startdate>19450119</startdate><enddate>19450119</enddate><creator>Chow, Bacon F.</creator><creator>McKee, Clara M.</creator><general>The Science Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19450119</creationdate><title>Interaction between Crystalline Penicillin and Human Plasma Proteins</title><author>Chow, Bacon F. ; McKee, Clara M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-42f766781e5d18f11c132d8ed2a2fe4c76b8d7ab6f9e2b6f5aa770763b5a9bfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1945</creationdate><topic>Albumins</topic><topic>Alcohols</topic><topic>Antibiotics</topic><topic>Blood proteins</topic><topic>Dialysis</topic><topic>Excretion</topic><topic>Penicillin</topic><topic>Salts</topic><topic>Serum albumins</topic><topic>Sodium</topic><topic>Special Articles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chow, Bacon F.</creatorcontrib><creatorcontrib>McKee, Clara M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chow, Bacon F.</au><au>McKee, Clara M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between Crystalline Penicillin and Human Plasma Proteins</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1945-01-19</date><risdate>1945</risdate><volume>101</volume><issue>2612</issue><spage>67</spage><epage>68</epage><pages>67-68</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1945-01, Vol.101 (2612), p.67-68 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733143058 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Albumins Alcohols Antibiotics Blood proteins Dialysis Excretion Penicillin Salts Serum albumins Sodium Special Articles |
| title | Interaction between Crystalline Penicillin and Human Plasma Proteins |
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