Interaction between Crystalline Penicillin and Human Plasma Proteins

Interaction between Crystalline Penicillin and Human Plasma Proteins

Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1945-01, Vol.101 (2612), p.67-68
Hauptverfasser: Chow, Bacon F., McKee, Clara M.
Format: Artikel
Sprache:eng
Schlagworte:
Albumins
Alcohols
Antibiotics
Blood proteins
Dialysis
Excretion
Penicillin
Salts
Serum albumins
Sodium
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Zusammenfassung:Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.101.2612.67